Radha Mahendran,Palani Muthu and Suba Sri Monograph on Genomics of Ageing Gene-Sirt1
SIRT1 gene codes for the protein ‘SIRTUINS’. SIRT1 gene is a candidate gene, involved in ageing process. The SIRT1 gene, whose activity is modified by the bodys metabolic state & was previously known to help control the process of ageing and extend the lifespan of humans, also plays a key role in regulating the internal clock. This important discovery helps to explain how the body regulates essential functions such as hormone production, body temperature & blood pressure, & may eventually lead to drugs to combat metabolic disorders, obesity or diabetes. Information related to functional SNPs in candidate disease genes is critical for cost effective genetic association studies, which attempt to understand the genetics of complex... By using Bioinformatics Tools & Softwares Exons, Introns, SNPs & RFLPs of SIRT1 were predicted. Ageing is a syndrome of changes that are deleterious, progressive, universal & thus irreversible. SNPs are consequently important in understanding human health.